When a woman kidnaps a man who had a DNA that had an unbreakable code, Mike runs after the female suspect. To stop the drag race smuggling ring that happens in the area, Mike asks for help from an ex-military friend. However, this buddy of his may have allies among these smugglers. Spying on the terrorist group in Baja, accused of snatching a powerful missile design created by Knight Research, Mike and Zoe pretend to be a couple.

Having been injected with a neural poison, Mike has only three hours left to live. If he could not kill the billionaire tech mogul, he would not be able to get the cure for the poison. While Mike infiltrates a right wing militia group plotting to make the dam explode, KITT pretends to be a 4×4 for an out-of-the-road mission. Later on, they discover a secret British agent pretending to be their ally. When a murderous hacker activates the self-destruct program inside KITT, Mike and Sarah has only half an hour left to back the system up and find out who the killer is. Mike and KITT search the couple that blows up buildings. Agent Rival is abducted by the couple and steals the confidential files of the SSC and plans to make the information available to the public via Internet. Mike goes to Las Vegas to catch the money laundering going on there. Billy, who recently joined the mission, gets involved in a romantic relationship.

Dr. Graiman gets face to face with an old rival. Mike attempts to a foreign ambassador kidnapped by a terrorist getting parts to make a hafnium nuclear bomb. Mike and KITT transport a terrorist nuclear bomb safely without detonating it. When her father dies from a bomb attack, Sarah grieves. Mike stops a bank heist. He goes to Colorado to investigate on the death of an ex-drill sergeant. Mike saves a boy-genius when the boy is kidnapped. When the owner of “Sonny’s Bar” gets killed, Mikes suspects foul play. When burglars steal the HXP serum that enhances human abilities, Mike and KITT go after them.